PROTECTION AGAINST FATAL RENAL INJURY DUE TO CHOLINE DEFICIENCY BY RENAL DECAPSULATION

Protection against Fatal Renal Injury Due to Choline Deficiency by Renal Decapsulation

Decapsulation of the left kidney through a lumbar incision immediately prior to placing young rats on a choline-deficient diet afforded a significant degree of protection against animal mortality, compared with that which occurred as a result of the deficiency in the control groups. Decapsulation also was effective in reducing greatly the renal injury which developed in the decapsulated kidneys...

Protection against renal ischemia reperfusion injury by CD44 disruption.

Inflammation contributes to renal ischemia reperfusion (I/R) injury, potentially causing renal dysfunction. The inflammatory infiltrate mainly consists of neutrophils, which are deleterious for the renal tissue. Because CD44 is expressed by neutrophils and is rapidly upregulated by capillary endothelial cells after I/R injury, it was hypothesized that CD44 might play an important role in the de...

Renal Lesions in Choline Deficiency in Rats

DURING the course of experiments with rats fed on a vitamin A deficient diet deaths occurred from a haemorrhagic degeneration of the kidneys. lThe changes foun(] in the kidneys resembled those described in choline deficiency by Griffith and Wade (1939). In their experiments the hwmorrhagic renal lesion was always accompanied by marked fatty degeneration of the liver, xvhile in our experiments t...

Renal Decapsulation in Puerperal Eclampsia

Prostaglandin-based renal protection against contrast-induced acute kidney injury.

It has been known for 3 decades that the kidneys rely considerably on a group of prostaglandins that are locally produced in both a constitutive and inducible fashion, primarily in the medulla, to regulate renal blood flow and a variety of functions in tubular cells that occupy that region of the kidney. Arachidonic acid released from phospholipids is converted by cyclooxygenase (COX-1 constitu...